Schedule your day:
Searching job boards during work hours is highly avoidable, as it might antagonize your present employers (unless you're a recruiter.) At home your responsibility is to your family and other personal commitments. This writes off a major chunk of your day, however jobs must be hunted, set aside two hours everyday for the sole purpose of job hunting. Setting RSS feeds matching your criteria for incoming positions is a good way to save time.
With a myriad of resources at your finger tips, there are so many things to do and so little time to do them in. Here are a few simple ways to get the most results, use a job aggregator like Indeed.com or Simply Hired, these pull jobs from 100's of sources to give you a well rounded idea off the job market. They combine various job boards, company websites and even some highly niche boards.
Another way to go is to set up keyword/hashtag searches on twitter to find any jobs posted by individuals that the aggregators did not pick up.
Lastly apply is not the only part of the process, u need to get your documentation ready, set aside time to build your resume, cover letter and do research on your various preferred companies.
Spreadsheets and job-tracking software are a hunters best friends. Keep all the places you've applied to neatly documented to avoid application redundancy. This also help you remember details if a employer responds.
Allocate time for interviews:
While you shouldn't take time out of your work day to job hunt, you will need to reserve time for interviews, both over the phone and in person. You don't want to risk your current position with frequent absences so schedule all interviews as early or late in the day as reasonable and comfortable for both parties.
Keep quite about interviews:
If you're like us regular mortals, the minute you get a call for an interview you'll want to run around telling everyone, but don't do that, even if your sure you'll get the job, don't get cocky, the deal is never done till the offer letter is sitting in your hand.
Take a vacation:
if you have vacation time saved up, use it now for some dedicated job hunting, try scheduling multiple jobs on one day, also use it to network and meet contacts to discuss job opportunities.
Don't keep quite about offers:
Be up front and open about any offers you might get to your boss, this might result in a more arrtactive counter offer. Be up front and give them as much notice as possible. Down the line you might need a recommendation, so keep your current employers impression of you sparkling clean.
Points to keep in mind:
The most important point is to keep your hunting quite in the office. If word gets out, your employers might either sack you or sit you down for a conversation you're not prepared for. If they find a replacement fast, it might hurt your income and put you in a difficult position. Make sure your friends and family know that you have something going on that will eat a significant chunk of your after-work time.